Ontology highlight
ABSTRACT:
SUBMITTER: Stedt H
PROVIDER: S-EPMC3390242 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Stedt Hanna H Alasaarela Laura L Samaranayake Haritha H Pikkarainen Jere J Määttä Ann-Marie AM Kholová Ivana I Parker Aaron S AS Ylä-Herttuala Seppo S
Molecular therapy. Nucleic acids 20120501
Malignant glioma is a severe cancer with a poor prognosis. Local occurrence and rare metastases of malignant glioma make it a suitable target for gene therapy. Several studies have demonstrated the importance of Src kinase in different cancers. However, these studies have focused mainly on Src-deficient mice or pharmacological inhibitors of Src. In this study we have used Src small hairpin RNAs (shRNAs) in a lentiviral backbone to mimic a long-term stable treatment and determined the role of Src ...[more]