Ontology highlight
ABSTRACT:
SUBMITTER: Schallenberg M
PROVIDER: S-EPMC3390333 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Schallenberg Maurice M Prokosch Verena V Thanos Solon S
PloS one 20120705 7
Examination of the response of the retinal proteome to elevated intraocular pressure (IOP) and to the pharmacological normalization of IOP is crucial, in order to develop drugs with neuroptorective potential. We used a hereditary rat model of ocular hypertension to lower IOP with travaprost and dorzolamide applied topically on the eye surface, and examine changes of the retinal proteome. Our data demonstrate that elevated IOP causes alterations in the retinal protein profile, in particular in hi ...[more]