Ontology highlight
ABSTRACT:
SUBMITTER: Golczak M
PROVIDER: S-EPMC3390653 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Golczak Marcin M Kiser Philip D PD Sears Avery E AE Lodowski David T DT Blaner William S WS Palczewski Krzysztof K
The Journal of biological chemistry 20120517 28
Lecithin:retinol acyltransferase-like proteins, also referred to as HRAS-like tumor suppressors, comprise a vertebrate subfamily of papain-like or NlpC/P60 thiol proteases that function as phospholipid-metabolizing enzymes. HRAS-like tumor suppressor 3, a representative member of this group, plays a key role in regulating triglyceride accumulation and energy expenditure in adipocytes and therefore constitutes a novel pharmacological target for treatment of metabolic disorders causing obesity. He ...[more]