Ontology highlight
ABSTRACT:
SUBMITTER: Chen G
PROVIDER: S-EPMC3390974 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Chen Gang G Cho Sung Jin SJ Huang Xi-Ping XP Jensen Niels H NH Svennebring Andreas A Sassano Maria F MF Roth Bryan L BL Kozikowski Alan P AP
ACS medicinal chemistry letters 20111010 12
The 5-HT(2C) receptor is an attractive drug target in the quest for new therapeutics to treat a variety of human disorders. We have previously undertaken a structural optimization campaign that has led to some potent and moderately selective 5-HT(2C) receptor agonists. After expanding our structure-function library, we were able to combine our datasets so as to allow the design of compounds of improved selectivity and potency. We disclose herein the structural optimization of our previously repo ...[more]