Ontology highlight
ABSTRACT:
SUBMITTER: Gwozdz T
PROVIDER: S-EPMC3391152 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Gwozdz Tomasz T Dutko-Gwozdz Joanna J Schafer Claudia C Bolotina Victoria M VM
The Journal of biological chemistry 20120501 27
Orai1 and STIM1 have been identified as the main determinants of the store-operated Ca(2+) entry (SOCE). Their specific roles in SOCE and their molecular interactions have been studied extensively following heterologous overexpression or molecular knockdown and extrapolated to the endogenous processes in naïve cells. Using molecular and imaging techniques, we found that variation of expression levels of Orai1 or STIM1 can significantly alter expression and role of some endogenous regulators of S ...[more]