Ontology highlight
ABSTRACT:
SUBMITTER: Sanderson SD
PROVIDER: S-EPMC3391237 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Sanderson Sam D SD Thoman Marilyn L ML Kis Kornelia K Virts Elizabeth L EL Herrera Edgar B EB Widmann Stephanie S Sepulveda Homero H Phillips Joy A JA
PloS one 20120706 7
The anaphylatoxin C5a is an especially potent mediator of both local and systemic inflammation. However, C5a also plays an essential role in mucosal host defense against bacterial, viral, and fungal infection. We have developed a response-selective agonist of human C5a, termed EP67, which retains the immunoenhancing activity of C5a at the expense of its inflammatory, anaphylagenic properties. EP67 insufflation results in the rapid induction of pulmonary cytokines and chemokines. This is followed ...[more]