Dataset Information

Socio-demographic characteristics of women sustaining injuries during pregnancy: a study from the Danish National Birth Cohort.

ABSTRACT:

Objectives

To describe adverse birth outcomes associated with hospital-treated injuries that took place among women in the Danish National Birth Cohort.

Design

Longitudinal cohort study.

Setting

Denmark.

Participants

90?452 women and their offspring selected from the Danish National Birth Cohort.

Primary and secondary outcome measures

To determine if injured women were more likely to deliver an infant preterm, with low birth weight, stillborn or have a spontaneous abortion, the authors estimated HRs. ORs were generated to assess APGAR scores and infants born small for gestational age (SGA). Models were adjusted for maternal smoking and drinking during pregnancy, household socioeconomic status, eclampsia/pre-eclampsia or gestational diabetes status during pregnancy and maternal age at birth; estimates for preterm birth were also adjusted for prior history of preterm birth.

Results

In the cohort of 90?452 pregnant women, 3561 (3.9%) received medical treatment for an injury during pregnancy. Injured pregnant women were more likely to deliver infants that were stillborn or have pregnancies terminated by spontaneous abortion. The authors did not detect an adverse effect between injuries sustained during pregnancy and delivery of preterm, low birth weight or SGA infants, or infants with an APGAR score of <7.

Conclusions

The study shows that injuries occurring among women from an unselected population may not have an adverse effect on birth weight, gestational age, APGAR score or SGA status but may adversely affect the risk of stillbirth and spontaneous abortions in some situations.

SUBMITTER: Virk J

PROVIDER: S-EPMC3391365 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Socio-demographic characteristics of women sustaining injuries during pregnancy: a study from the Danish National Birth Cohort.

Virk Jasveer J Hsu Paul P Olsen Jørn J

BMJ open 20120702 4

<h4>Objectives</h4>To describe adverse birth outcomes associated with hospital-treated injuries that took place among women in the Danish National Birth Cohort.<h4>Design</h4>Longitudinal cohort study.<h4>Setting</h4>Denmark.<h4>Participants</h4>90 452 women and their offspring selected from the Danish National Birth Cohort.<h4>Primary and secondary outcome measures</h4>To determine if injured women were more likely to deliver an infant preterm, with low birth weight, stillborn or have a spontan ...[more]

PMID: 22761281

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Project description:ObjectivesParticipation in population-based surveys and epidemiological studies has been declining over the years in many countries. The aim of this study was to examine the association between job type and participation in the work environment and health in Denmark survey with/without taking into account other socio-demographic factors.DesignCross-sectional survey using questionnaire data on working environment and registry data on job type, industry and socio-economic variables.SettingThe work environment and health study.ParticipantsA total of 50?806 employees (15?767 in a stratified workplace sample; 35?039 in a random sample) working at least 35 hours/month and earning at least 3000 Danish Krones.Outcome measuresThe outcome was participation (yes/no) and logistic regression was used to estimate the OR for participation with 95% CI.ResultsIn the random sample, women were more likely to participate than men, and married/non-married couples were more likely to participate than persons living alone or more families living together. Participation increased with higher age, higher annual personal income, higher education and Danish origin, and there were marked differences in participation between job types and geographical regions. For armed forces, craft and related trade workers, and skilled agricultural, forestry and fishery workers, the association between job type and participation was strongly attenuated after adjustment for sex and age. Additional adjustment for annual income, education, cohabitation, country of origin and geographical region generally attenuated the association between job type and participation. Similar results were found in the stratified workplace sample.ConclusionIn this population of Danish employees, participation varied across types of jobs. Some but not all the variation between job types was explained by other socio-demographic factors. Future studies using questionnaires may consider targeting efforts to (sub-)populations, defined by job type and other factors, where response probability is particularly important.

Project description:BACKGROUND:Maternal thyroid hormones are essential for fetal brain development in early gestation. Perfluoroalkyl substances (PFASs)-widespread and persistent pollutants-have been suggested to interfere with maternal thyroid hormones in the second or third trimesters, but evidence for an association in the early pregnancy period is sparse. OBJECTIVES:Our goal was to evaluate the gestational-week specific associations of maternal thyroid-stimulating hormone (TSH) and free thyroxine (fT4) levels with plasma concentrations of six PFAS chemicals in the first and second pregnancy trimester. METHODS:A cross-sectional analysis was conducted using 1,366 maternal blood samples collected between gestational weeks (GWs) 5 and 19 (median, 8 gestational weeks) in the Danish National Birth Cohort (DNBC) during 1996-2002. We estimated the percentage changes of serum TSH and fT4 levels according to concentrations (in nanograms per milliliter) of six PFAS chemicals modeled as per interquartile range (IQR) increase or by exposure quartiles. Moreover, we contrasted the estimated week-specific TSH or fT4 levels by PFAS quartile and estimated ORs for binary high or low TSH and fT4 status based on the week-specific distribution according to IQR increase of PFAS. RESULTS:TSH levels followed a U-curve trend in early pregnancy with a nadir at GW10, whereas fT4 levels were less fluctuated in the samples. There were no apparent associations between any of the PFASs and changes of average TSH or fT4 levels in total samples. In gestational-week-specific analyses, we found that the estimated TSH values were higher among the highest perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), perfluorohexane sulfonate (PFHxS), and perfluoroheptane sulfonate (PFHpS) quartiles compared with the lower quartiles from GW5 to GW10, but the difference became null or even reversed after GW10. For binary outcomes, perfluorodecanoic acid (PFDA) was associated with high fT4 status before GW10 [OR=1.46 (95% CI: 1.04, 2.05)]. CONCLUSIONS:We observed some gestational-week-specific associations between high exposure to several PFAS and TSH level in early gestations. Further research of the biology and the potential clinical impact regarding thyroid hormones disruptions in early pregnancy is needed. https://doi.org/10.1289/EHP5482.

Dataset Information

Socio-demographic characteristics of women sustaining injuries during pregnancy: a study from the Danish National Birth Cohort.

Objectives

Design

Setting

Participants

Primary and secondary outcome measures

Results

Conclusions

Publications

Socio-demographic characteristics of women sustaining injuries during pregnancy: a study from the Danish National Birth Cohort.

Similar Datasets

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