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ABSTRACT: Introduction
Acute pain is a hallmark of sickle cell disease (SCD) for which frequent hospital admissions may be required, affecting the quality of life of patients.Objectives
To characterise the relationship between adult patient self-reported sickle cell pain, mood and quality of life during and after hospital admissions.Design
Longitudinal study across three time-points.Setting
Secondary care, single specialist sickle cell centre.Participants
510 adult patients with SCD admitted to hospital daycare or inpatient units.Outcome measures
Self-assessments of pain, mood and health-related quality of life with health utility (measured on the EQ-5D) on admission, before discharge and at 1-week postdischarge.Results
Mood, general health and quality of life showed significant steady improvements with reduction of pain in patients with SCD on admission to hospital, before discharge and at 1-week follow-up (p<0.01). Health utility scores derived from the EQ-5D showed a negative association with pain in regression analysis over the three time-points.Conclusion
Examining health-related quality of life and health utility in relation to pain during hospital admissions is valuable in terms of targeting appropriate psychological interventions within the context of a multidisciplinary approach to managing sickle cell pain. This has implications for healthcare costs.
SUBMITTER: Anie KA
PROVIDER: S-EPMC3391376 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Anie Kofi A KA Grocott Hannah H White Lauren L Dzingina Mendwas M Rogers Gabriel G Cho Gavin G
BMJ open 20120702 4
<h4>Introduction</h4>Acute pain is a hallmark of sickle cell disease (SCD) for which frequent hospital admissions may be required, affecting the quality of life of patients.<h4>Objectives</h4>To characterise the relationship between adult patient self-reported sickle cell pain, mood and quality of life during and after hospital admissions.<h4>Design</h4>Longitudinal study across three time-points.<h4>Setting</h4>Secondary care, single specialist sickle cell centre.<h4>Participants</h4>510 adult ...[more]