Ontology highlight
ABSTRACT:
SUBMITTER: Szabo R
PROVIDER: S-EPMC3391589 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Szabo Roman R Bugge Thomas H TH
Annual review of cell and developmental biology 20110629
Analysis of vertebrate genome sequences at the turn of the millennium revealed that a vastly larger repertoire of enzymes execute proteolytic cleavage reactions within the pericellular and extracellular environments than was anticipated from biochemical and molecular analysis. Most unexpected was the unveiling of an entire new family of structurally unique multidomain serine proteases that are anchored directly to the plasma membrane. Unlike secreted serine proteases, which function primarily in ...[more]