Coanalysis of GWAS with eQTLs reveals disease-tissue associations.
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ABSTRACT:
SUBMITTER: Kang HP
PROVIDER: S-EPMC3392070 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Publications
Coanalysis of GWAS with eQTLs reveals disease-tissue associations.
Kang Hyunseok Peter HP Morgan Alex A AA Chen Rong R Schadt Eric E EE Butte Atul J AJ
AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science 20120319
Expression quantitative trait loci (eQTL), or genetic variants associated with changes in gene expression, have the potential to assist in interpreting results of genome-wide association studies (GWAS). eQTLs also have varying degrees of tissue specificity. By correlating the statistical significance of eQTLs mapped in various tissue types to their odds ratios reported in a large GWAS by the Wellcome Trust Case Control Consortium (WTCCC), we discovered that there is a significant association bet ...[more]
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