Ontology highlight
ABSTRACT:
SUBMITTER: Griswold AJ
PROVIDER: S-EPMC3392110 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Griswold Anthony J AJ Ma Deqiong D Cukier Holly N HN Nations Laura D LD Schmidt Mike A MA Chung Ren-Hua RH Jaworski James M JM Salyakina Daria D Konidari Ioanna I Whitehead Patrice L PL Wright Harry H HH Abramson Ruth K RK Williams Scott M SM Menon Ramkumar R Martin Eden R ER Haines Jonathan L JL Gilbert John R JR Cuccaro Michael L ML Pericak-Vance Margaret A MA
Human molecular genetics 20120427 15
Autism spectrum disorders (ASDs) are highly heritable, yet relatively few associated genetic loci have been replicated. Copy number variations (CNVs) have been implicated in autism; however, the majority of loci contribute to <1% of the disease population. Therefore, independent studies are important to refine associated CNV regions and discover novel susceptibility genes. In this study, a genome-wide SNP array was utilized for CNV detection by two distinct algorithms in a European ancestry case ...[more]