ADAM10 mediates vascular injury induced by Staphylococcus aureus ?-hemolysin.
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ABSTRACT:
SUBMITTER: Powers ME
PROVIDER: S-EPMC3392186 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Publications
ADAM10 mediates vascular injury induced by Staphylococcus aureus α-hemolysin.
Powers Michael E ME Kim Hwan Keun HK Wang Yang Y Bubeck Wardenburg Juliane J
The Journal of infectious diseases 20120402 3
Staphylococcus aureus is a leading cause of bacteremia and sepsis. The interaction of S. aureus with the endothelium is central to bloodstream infection pathophysiology yet remains ill-understood. We show herein that staphylococcal α-hemolysin, a pore-forming cytotoxin, is required for full virulence in a murine sepsis model. The α-hemolysin binding to its receptor A-disintegrin and metalloprotease 10 (ADAM10) upregulates the receptor's metalloprotease activity on endothelial cells, causing vasc ...[more]
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