Ontology highlight
ABSTRACT:
SUBMITTER: Denton D
PROVIDER: S-EPMC3392632 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Denton D D Chang T-K TK Nicolson S S Shravage B B Simin R R Baehrecke E H EH Kumar S S
Cell death and differentiation 20120504 8
Autophagy has been implicated in both cell survival and programmed cell death (PCD), and this may explain the apparently complex role of this catabolic process in tumourigenesis. Our previous studies have shown that caspases have little influence on Drosophila larval midgut PCD, whereas inhibition of autophagy severely delays midgut removal. To assess upstream signals that regulate autophagy and larval midgut degradation, we have examined the requirement of growth signalling pathways. Inhibition ...[more]