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Lack of interference with immunogenicity of a chimeric alphavirus replicon particle-based influenza vaccine by preexisting antivector immunity.

ABSTRACT: Antivector immunity has been recognized as a potential caveat of using virus-based vaccines. In the present study, an alphavirus-based replicon particle vaccine platform, which has demonstrated robust immunogenicity in animal models, was tested for effects of antivector immunity on immunogenicity against hemagglutinin of influenza virus as a target antigen and efficacy for protection against lethal challenge with the virus. Chimeric alphavirus-based replicon particles, comprising Venezuelan equine encephalitis virus nonstructural and Sindbis virus structural components, induced efficient protective antibody responses, which were not adversely influenced after multiple immunizations with the same vector expressing various antigens.

SUBMITTER: Uematsu Y 

PROVIDER: S-EPMC3393363 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature

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Lack of interference with immunogenicity of a chimeric alphavirus replicon particle-based influenza vaccine by preexisting antivector immunity.

Uematsu Yasushi Y   Vajdy Michael M   Lian Ying Y   Perri Silvia S   Greer Catherine E CE   Legg Harold S HS   Galli Grazia G   Saletti Giulietta G   Otten Gillis R GR   Rappuoli Rino R   Barnett Susan W SW   Polo John M JM  

Clinical and vaccine immunology : CVI 20120523 7

Antivector immunity has been recognized as a potential caveat of using virus-based vaccines. In the present study, an alphavirus-based replicon particle vaccine platform, which has demonstrated robust immunogenicity in animal models, was tested for effects of antivector immunity on immunogenicity against hemagglutinin of influenza virus as a target antigen and efficacy for protection against lethal challenge with the virus. Chimeric alphavirus-based replicon particles, comprising Venezuelan equi  ...[more]

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