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Chromosome-encoded extended-spectrum class A ?-lactamase MIN-1 from Minibacterium massiliensis.


ABSTRACT: Minibacterium massiliensis strain CIP107820 is a recently discovered waterborne Gram-negative rod isolated from hospital water samples. It harbors a chromosomally located gene encoding an Ambler class A extended-spectrum ?-lactamase termed MIN-1, sharing 56%, 54%, and 51% amino acid identities with ?-lactamases LUT-1, KPC-2, and CTX-M-2, respectively. ?-Lactamase MIN-1 hydrolyzes penicillins, narrow-spectrum cephalosporins, cefotaxime, and, less efficiently, cefepime, while ceftazidime and carbapenems are very poor substrates, and cephamycins and aztreonam are not hydrolyzed.

SUBMITTER: Bercot B 

PROVIDER: S-EPMC3393436 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature

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Chromosome-encoded extended-spectrum class A β-lactamase MIN-1 from Minibacterium massiliensis.

Bercot Béatrice B   Nordmann Patrice P   Drancourt Michel M   Poirel Laurent L  

Antimicrobial agents and chemotherapy 20120423 7


Minibacterium massiliensis strain CIP107820 is a recently discovered waterborne Gram-negative rod isolated from hospital water samples. It harbors a chromosomally located gene encoding an Ambler class A extended-spectrum β-lactamase termed MIN-1, sharing 56%, 54%, and 51% amino acid identities with β-lactamases LUT-1, KPC-2, and CTX-M-2, respectively. β-Lactamase MIN-1 hydrolyzes penicillins, narrow-spectrum cephalosporins, cefotaxime, and, less efficiently, cefepime, while ceftazidime and carba  ...[more]

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