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Pharmacokinetics of intraperitoneal and intravenous fosfomycin in automated peritoneal dialysis patients without peritonitis.


ABSTRACT: Blood and dialysate concentrations of fosfomycin were determined after intravenous and intraperitoneal application of 4 mg/liter in patients undergoing automated peritoneal dialysis. Maximum serum concentrations after intravenous (287.75 ± 86.34 mg/liter) and intraperitoneal (205.78 ± 66.78 mg/liter) administration were comparable. Ratios of intraperitoneal to systemic exposure were 1.12 (intraperitoneal administration) and 0.22 (intravenous administration), indicating good systemic exposure after intraperitoneal application but limited penetration of fosfomycin into the peritoneal fluid after the intravenous dose.

SUBMITTER: Tobudic S 

PROVIDER: S-EPMC3393440 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature

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Pharmacokinetics of intraperitoneal and intravenous fosfomycin in automated peritoneal dialysis patients without peritonitis.

Tobudic Selma S   Matzneller Peter P   Stoiser Brigitte B   Wenisch Judith Maria JM   Zeitlinger Markus M   Vychytil Andreas A   Jaeger Walter W   Boehmdorfer Michaela M   Reznicek Gottfried G   Burgmann Heinz H  

Antimicrobial agents and chemotherapy 20120507 7


Blood and dialysate concentrations of fosfomycin were determined after intravenous and intraperitoneal application of 4 mg/liter in patients undergoing automated peritoneal dialysis. Maximum serum concentrations after intravenous (287.75 ± 86.34 mg/liter) and intraperitoneal (205.78 ± 66.78 mg/liter) administration were comparable. Ratios of intraperitoneal to systemic exposure were 1.12 (intraperitoneal administration) and 0.22 (intravenous administration), indicating good systemic exposure aft  ...[more]

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