Ontology highlight
ABSTRACT:
SUBMITTER: Tekes G
PROVIDER: S-EPMC3393577 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Tekes Gergely G Spies Danica D Bank-Wolf Barbara B Thiel Volker V Thiel Heinz-Jürgen HJ
Journal of virology 20120404 12
Feline infectious peritonitis (FIP) is a lethal immunopathological disease caused by feline coronaviruses (FCoVs). Here, we describe a reverse genetics approach to study FIP by assessing the pathogenicity of recombinant type I and type II and chimeric type I/type II FCoVs. All recombinant FCoVs established productive infection in cats, and recombinant type II FCoV (strain 79-1146) induced FIP. Virus sequence analyses from FIP-diseased cats revealed that the 3c gene stop codon of strain 79-1146 h ...[more]