Ontology highlight
ABSTRACT:
SUBMITTER: Wong WC
PROVIDER: S-EPMC3394259 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Wong Wing-Cheong WC Maurer-Stroh Sebastian S Schneider Georg G Eisenhaber Frank F
Nucleic acids research 20120507 Web Server issue
Transmembrane helical segments (TMs) can be classified into two groups of so-called 'simple' and 'complex' TMs. Whereas the first group represents mere hydrophobic anchors with an overrepresentation of aliphatic hydrophobic residues that are likely attributed to convergent evolution in many cases, the complex ones embody ancestral information and tend to have structural and functional roles beyond just membrane immersion. Hence, the sequence homology concept is not applicable on simple TMs. In p ...[more]