Ontology highlight
ABSTRACT:
SUBMITTER: Schultz AK
PROVIDER: S-EPMC3394342 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Schultz Anne-Kathrin AK Bulla Ingo I Abdou-Chekaraou Mariama M Gordien Emmanuel E Morgenstern Burkhard B Zoaulim Fabien F Dény Paul P Stanke Mario M
Nucleic acids research 20120516 Web Server issue
jpHMM is a very accurate and widely used tool for recombination detection in genomic sequences of HIV-1. Here, we present an extension of jpHMM to analyze recombinations in viruses with circular genomes such as the hepatitis B virus (HBV). Sequence analysis of circular genomes is usually performed on linearized sequences using linear models. Since linear models are unable to model dependencies between nucleotides at the 5'- and 3'-end of a sequence, this can result in inaccurate predictions of r ...[more]