Ontology highlight
ABSTRACT:
SUBMITTER: Chen YL
PROVIDER: S-EPMC3394400 | biostudies-literature | 2008 Apr
REPOSITORIES: biostudies-literature
Chen Yulong L YL Law Ping-Yee PY Loh Horace H HH
Biochemical and biophysical research communications 20080211 3
The G protein-coupled delta opioid receptor gene (dor) has been associated with neuronal survival, differentiation, and neuroprotection. Our previous study identified PI3K/Akt/NF-kappaB signaling is a main downstream signaling pathway in nerve growth factor (NGF)-induced temporal expression of the dor gene in the PC12 cell model. It is still unknown how NGF/PI3K signaling regulates the expression of the dor gene in the nucleus. In the current study, we investigated how PI3K signaling affected ep ...[more]