Effect of alkyl chain length on sphingosine kinase 2 selectivity.
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ABSTRACT:
SUBMITTER: Knott K
PROVIDER: S-EPMC3394931 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Publications
Effect of alkyl chain length on sphingosine kinase 2 selectivity.
Knott Kenneth K Kharel Yugesh Y Raje Mithun R MR Lynch Kevin R KR Santos Webster L WL
Bioorganic & medicinal chemistry letters 20120126 22
The conversion of sphingosine to sphingosine-1-phosphate is catalyzed by sphingosine kinase (SphK), which has been implicated in disease states such as cancer and fibrosis. Because SphK exists as two different isoforms, SphK1 and SphK2, understanding the physiological function of each isoenzyme is important. Of the two isoenzymes, SphK2 is significantly less understood, which is evident by the lack of selective small molecule inhibitors. Building on our initial work that focused on the structure ...[more]
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