Notch and Mef2 synergize to promote proliferation and metastasis through JNK signal activation in Drosophila.
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ABSTRACT:
SUBMITTER: Pallavi SK
PROVIDER: S-EPMC3395089 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Publications
Notch and Mef2 synergize to promote proliferation and metastasis through JNK signal activation in Drosophila.
Pallavi S K SK Ho Diana M DM Hicks Chindo C Miele Lucio L Artavanis-Tsakonas Spyros S
The EMBO journal 20120511 13
Genetic analyses in Drosophila revealed a synergy between Notch and the pleiotropic transcription factor Mef2 (myocyte enhancer factor 2), which profoundly influences proliferation and metastasis. We show that these hyperproliferative and invasive Drosophila phenotypes are attributed to upregulation of eiger, a member of the tumour necrosis factor superfamily of ligands, and the consequent activation of Jun N-terminal kinase signalling, which in turn triggers the expression of the invasive marke ...[more]
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