Ontology highlight
ABSTRACT:
SUBMITTER: Macfarlan TS
PROVIDER: S-EPMC3395470 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Macfarlan Todd S TS Gifford Wesley D WD Driscoll Shawn S Lettieri Karen K Rowe Helen M HM Bonanomi Dario D Firth Amy A Singer Oded O Trono Didier D Pfaff Samuel L SL
Nature 20120701 7405
Embryonic stem (ES) cells are derived from blastocyst-stage embryos and are thought to be functionally equivalent to the inner cell mass, which lacks the ability to produce all extraembryonic tissues. Here we identify a rare transient cell population within mouse ES and induced pluripotent stem (iPS) cell cultures that expresses high levels of transcripts found in two-cell (2C) embryos in which the blastomeres are totipotent. We genetically tagged these 2C-like ES cells and show that they lack t ...[more]