Control of virulence by small RNAs in Streptococcus pneumoniae.
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ABSTRACT:
SUBMITTER: Mann B
PROVIDER: S-EPMC3395615 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Publications
Control of virulence by small RNAs in Streptococcus pneumoniae.
Mann Beth B van Opijnen Tim T Wang Jianmin J Obert Caroline C Wang Yong-Dong YD Carter Robert R McGoldrick Daniel J DJ Ridout Granger G Camilli Andrew A Tuomanen Elaine I EI Rosch Jason W JW
PLoS pathogens 20120712 7
Small noncoding RNAs (sRNAs) play important roles in gene regulation in both prokaryotes and eukaryotes. Thus far, no sRNA has been assigned a definitive role in virulence in the major human pathogen Streptococcus pneumoniae. Based on the potential coding capacity of intergenic regions, we hypothesized that the pneumococcus produces many sRNAs and that they would play an important role in pathogenesis. We describe the application of whole-genome transcriptional sequencing to systematically ident ...[more]
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