Ontology highlight
ABSTRACT:
SUBMITTER: Tao T
PROVIDER: S-EPMC3395653 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Molecular biology of the cell 20120516 14
The Notch signaling regulator Numblike (Numbl) is expressed in the brain, but little is known regarding its role in the pathophysiology of glial cells. In this paper, we report that Numbl expression was down-regulated in high-grade human glioma tissue samples and glioblastoma cell lines. To investigate the role of Numbl in glioma migration and invasion, we generated human glioma cell lines in which Numbl was either overexpressed or depleted. Overexpression of Numbl suppressed, while elimination ...[more]