Ontology highlight
ABSTRACT:
SUBMITTER: Sanz AB
PROVIDER: S-EPMC3395667 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Sanz A Belén AB Sanz A Belén AB García Raúl R Rodríguez-Peña Jose Manuel JM Díez-Muñiz Sonia S Nombela César C Peterson Craig L CL Arroyo Javier J
Molecular biology of the cell 20120523 14
In Saccharomyces cerevisiae, the transcriptional program triggered by cell wall stress is coordinated by Slt2/Mpk1, the mitogen-activated protein kinase (MAPK) of the cell wall integrity (CWI) pathway, and is mostly mediated by the transcription factor Rlm1. Here we show that the SWI/SNF chromatin-remodeling complex plays a critical role in orchestrating the transcriptional response regulated by Rlm1. swi/snf mutants show drastically reduced expression of cell wall stress-responsive genes and hy ...[more]