Unknown

Dataset Information

0

Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study.

ABSTRACT: Prostate cancer (PrCa) is the most frequently diagnosed male cancer in developed countries. We conducted a multi-stage genome-wide association study for PrCa and previously reported the results of the first two stages, which identified 16 PrCa susceptibility loci. We report here the results of stage 3, in which we evaluated 1,536 SNPs in 4,574 individuals with prostate cancer (cases) and 4,164 controls. We followed up ten new association signals through genotyping in 51,311 samples in 30 studies from the Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL) consortium. In addition to replicating previously reported loci, we identified seven new prostate cancer susceptibility loci on chromosomes 2p11, 3q23, 3q26, 5p12, 6p21, 12q13 and Xq12 (P = 4.0 × 10(-8) to P = 2.7 × 10(-24)). We also identified a SNP in TERT more strongly associated with PrCa than that previously reported. More than 40 PrCa susceptibility loci, explaining ?25% of the familial risk in this disease, have now been identified.

SUBMITTER: Kote-Jarai Z 

PROVIDER: S-EPMC3396006 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study.

Kote-Jarai Zsofia Z   Olama Ali Amin Al AA   Giles Graham G GG   Severi Gianluca G   Schleutker Johanna J   Weischer Maren M   Campa Daniele D   Riboli Elio E   Key Tim T   Gronberg Henrik H   Hunter David J DJ   Kraft Peter P   Thun Michael J MJ   Ingles Sue S   Chanock Stephen S   Albanes Demetrius D   Hayes Richard B RB   Neal David E DE   Hamdy Freddie C FC   Donovan Jenny L JL   Pharoah Paul P   Schumacher Fredrick F   Henderson Brian E BE   Stanford Janet L JL   Ostrander Elaine A EA   Sorensen Karina Dalsgaard KD   Dörk Thilo T   Andriole Gerald G   Dickinson Joanne L JL   Cybulski Cezary C   Lubinski Jan J   Spurdle Amanda A   Clements Judith A JA   Chambers Suzanne S   Aitken Joanne J   Gardiner R A Frank RA   Thibodeau Stephen N SN   Schaid Dan D   John Esther M EM   Maier Christiane C   Vogel Walther W   Cooney Kathleen A KA   Park Jong Y JY   Cannon-Albright Lisa L   Brenner Hermann H   Habuchi Tomonori T   Zhang Hong-Wei HW   Lu Yong-Jie YJ   Kaneva Radka R   Muir Ken K   Benlloch Sara S   Leongamornlert Daniel A DA   Saunders Edward J EJ   Tymrakiewicz Malgorzata M   Mahmud Nadiya N   Guy Michelle M   O'Brien Lynne T LT   Wilkinson Rosemary A RA   Hall Amanda L AL   Sawyer Emma J EJ   Dadaev Tokhir T   Morrison Jonathan J   Dearnaley David P DP   Horwich Alan A   Huddart Robert A RA   Khoo Vincent S VS   Parker Christopher C CC   Van As Nicholas N   Woodhouse Christopher J CJ   Thompson Alan A   Christmas Tim T   Ogden Chris C   Cooper Colin S CS   Lophatonanon Aritaya A   Southey Melissa C MC   Hopper John L JL   English Dallas R DR   Wahlfors Tiina T   Tammela Teuvo L J TL   Klarskov Peter P   Nordestgaard Børge G BG   Røder M Andreas MA   Tybjærg-Hansen Anne A   Bojesen Stig E SE   Travis Ruth R   Canzian Federico F   Kaaks Rudolf R   Wiklund Fredrik F   Aly Markus M   Lindstrom Sara S   Diver W Ryan WR   Gapstur Susan S   Stern Mariana C MC   Corral Roman R   Virtamo Jarmo J   Cox Angela A   Haiman Christopher A CA   Le Marchand Loic L   Fitzgerald Liesel L   Kolb Suzanne S   Kwon Erika M EM   Karyadi Danielle M DM   Orntoft Torben Falck TF   Borre Michael M   Meyer Andreas A   Serth Jürgen J   Yeager Meredith M   Berndt Sonja I SI   Marthick James R JR   Patterson Briony B   Wokolorczyk Dominika D   Batra Jyotsna J   Lose Felicity F   McDonnell Shannon K SK   Joshi Amit D AD   Shahabi Ahva A   Rinckleb Antje E AE   Ray Ana A   Sellers Thomas A TA   Lin Hui-Yi HY   Stephenson Robert A RA   Farnham James J   Muller Heiko H   Rothenbacher Dietrich D   Tsuchiya Norihiko N   Narita Shintaro S   Cao Guang-Wen GW   Slavov Chavdar C   Mitev Vanio V   Easton Douglas F DF   Eeles Rosalind A RA  

Nature genetics 20110710 8

Prostate cancer (PrCa) is the most frequently diagnosed male cancer in developed countries. We conducted a multi-stage genome-wide association study for PrCa and previously reported the results of the first two stages, which identified 16 PrCa susceptibility loci. We report here the results of stage 3, in which we evaluated 1,536 SNPs in 4,574 individuals with prostate cancer (cases) and 4,164 controls. We followed up ten new association signals through genotyping in 51,311 samples in 30 studies  ...[more]

Similar Datasets

Unknown Identification of seven new prostate cancer susceptibility loci through a genome-wide association study.
| S-EPMC2846760 | biostudies-literature
Unknown Susceptibility loci for metabolic syndrome and metabolic components identified in Han Chinese: a multi-stage genome-wide association study.
| S-EPMC5431133 | biostudies-literature
Unknown A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci.
| S-EPMC3049891 | biostudies-literature
Unknown 12 new susceptibility loci for prostate cancer identified by genome-wide association study in Japanese population.
| S-EPMC6764957 | biostudies-literature
Unknown Genome-wide association study identifies new prostate cancer susceptibility loci.
| S-EPMC3168287 | biostudies-literature
Unknown Genome-wide association study identifies seven novel susceptibility loci for primary open-angle glaucoma.
| S-EPMC6251544 | biostudies-literature
Unknown Nine susceptibility loci for hepatitis B virus-related hepatocellular carcinoma identified by a pilot two-stage genome-wide association study.
| S-EPMC4727098 | biostudies-literature
Unknown Genome-wide interaction-based association analysis identified multiple new susceptibility Loci for common diseases.
| S-EPMC3060075 | biostudies-literature
Unknown Functional annotation of risk loci identified through genome-wide association studies for prostate cancer.
| S-EPMC3070182 | biostudies-literature
Unknown Genome-wide association analyses identified novel susceptibility loci for pulmonary embolism among Han Chinese population.
| S-EPMC10116678 | biostudies-literature