Ontology highlight
ABSTRACT:
SUBMITTER: Sunshine SB
PROVIDER: S-EPMC3396467 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Sunshine Sarah B SB Dallabrida Susan M SM Durand Ellen E Ismail Nesreen S NS Bazinet Lauren L Birsner Amy E AE Sohn Regina R Ikeda Sadakatsu S Pu William T WT Kulke Matthew H MH Javaherian Kashi K Zurakowski David D Folkman Judah M JM Rupnick Maria M
Proceedings of the National Academy of Sciences of the United States of America 20120625 28
Antiangiogenesis therapy has become a vital part of the armamentarium against cancer. Hypertension is a dose-limiting toxicity for VEGF inhibitors. Thus, there is a pressing need to address the associated adverse events so these agents can be better used. The hypertension may be mediated by reduced NO bioavailability resulting from VEGF inhibition. We proposed that the hypertension may be prevented by coadministration with endostatin (ES), an endogenous angiogenesis inhibitor with antitumor effe ...[more]