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Nomenclature report on the major histocompatibility complex genes and alleles of Great Ape, Old and New World monkey species.


ABSTRACT: The major histocompatibility complex (MHC) plays a central role in the adaptive immune response. The MHC region is characterised by a high gene density, and most of these genes display considerable polymorphism. Next to humans, non-human primates (NHP) are well studied for their MHC. The present nomenclature report provides the scientific community with the latest nomenclature guidelines/rules and current implemented nomenclature revisions for Great Ape, Old and New World monkey species. All the currently published MHC data for the different Great Ape, Old and New World monkey species are archived at the Immuno Polymorphism Database (IPD)-MHC NHP database. The curators of the IPD-MHC NHP database are, in addition, responsible for providing official designations for newly detected polymorphisms.

SUBMITTER: de Groot NG 

PROVIDER: S-EPMC3396756 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature

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Nomenclature report on the major histocompatibility complex genes and alleles of Great Ape, Old and New World monkey species.

de Groot Natasja G NG   Otting Nel N   Robinson James J   Blancher Antoine A   Lafont Bernard A P BA   Marsh Steven G E SG   O'Connor David H DH   Shiina Takashi T   Walter Lutz L   Watkins David I DI   Bontrop Ronald E RE  

Immunogenetics 20120418 8


The major histocompatibility complex (MHC) plays a central role in the adaptive immune response. The MHC region is characterised by a high gene density, and most of these genes display considerable polymorphism. Next to humans, non-human primates (NHP) are well studied for their MHC. The present nomenclature report provides the scientific community with the latest nomenclature guidelines/rules and current implemented nomenclature revisions for Great Ape, Old and New World monkey species. All the  ...[more]

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