Ontology highlight
ABSTRACT:
SUBMITTER: O'Donnell CJ
PROVIDER: S-EPMC3397173 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
O'Donnell Christopher J CJ Kavousi Maryam M Smith Albert V AV Kardia Sharon L R SL Feitosa Mary F MF Hwang Shih-Jen SJ Sun Yan V YV Province Michael A MA Aspelund Thor T Dehghan Abbas A Hoffmann Udo U Bielak Lawrence F LF Zhang Qunyuan Q Eiriksdottir Gudny G van Duijn Cornelia M CM Fox Caroline S CS de Andrade Mariza M Kraja Aldi T AT Sigurdsson Sigurdur S Elias-Smale Suzette E SE Murabito Joanne M JM Launer Lenore J LJ van der Lugt Aad A Kathiresan Sekar S Krestin Gabriel P GP Herrington David M DM Howard Timothy D TD Liu Yongmei Y Post Wendy W Mitchell Braxton D BD O'Connell Jeffrey R JR Shen Haiqing H Shuldiner Alan R AR Altshuler David D Elosua Roberto R Salomaa Veikko V Schwartz Stephen M SM Siscovick David S DS Voight Benjamin F BF Bis Joshua C JC Glazer Nicole L NL Psaty Bruce M BM Boerwinkle Eric E Heiss Gerardo G Blankenberg Stefan S Zeller Tanja T Wild Philipp S PS Schnabel Renate B RB Schillert Arne A Ziegler Andreas A Münzel Thomas F TF White Charles C CC Rotter Jerome I JI Nalls Michael M Oudkerk Matthijs M Johnson Andrew D AD Newman Anne B AB Uitterlinden Andre G AG Massaro Joseph M JM Cunningham Julie J Harris Tamara B TB Hofman Albert A Peyser Patricia A PA Borecki Ingrid B IB Cupples L Adrienne LA Gudnason Vilmundur V Witteman Jacqueline C M JC
Circulation 20111205 25
<h4>Background</h4>Coronary artery calcification (CAC) detected by computed tomography is a noninvasive measure of coronary atherosclerosis, which underlies most cases of myocardial infarction (MI). We sought to identify common genetic variants associated with CAC and further investigate their associations with MI.<h4>Methods and results</h4>Computed tomography was used to assess quantity of CAC. A meta-analysis of genome-wide association studies for CAC was performed in 9961 men and women from ...[more]