Ontology highlight
ABSTRACT:
SUBMITTER: Bzowska M
PROVIDER: S-EPMC3397235 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Bzowska Małgorzata M Nogieć Anna A Skrzeczyńska-Moncznik Joanna J Mickowska Barbara B Guzik Krzysztof K Pryjma Juliusz J
Inflammation 20120801 4
It is widely accepted that oxidized low-density lipoproteins and local infections or endotoxins in circulation contribute to chronic inflammatory process at all stages of atherosclerosis. The hallmark cells of atherosclerotic lesions-monocytes and macrophages-are able to detect and integrate complex signals derived from lipoproteins and pathogens, and respond with a spectrum of immunoregulatory cytokines. In this study, we show strong inhibitory effect of oxLDLs on anti-inflammatory interleukin- ...[more]