Ontology highlight
ABSTRACT:
SUBMITTER: Li H
PROVIDER: S-EPMC3397246 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Li Hui H Liu Lei L Xing Da D Chen Wei R WR
FEBS letters 20101029 22
Here we studied the mechanism by which heat shock protein 70 (Hsp70) prevents Bax activation during ultraviolet (UV)-induced apoptosis. UV treatment led to c-Jun N-terminal kinase (JNK) phosphorylation, Bim redistribution and subsequent Bax activation. Bim depletion caused a smaller reduction in apoptosis than that by JNK inhibition, indicating that Bim activation is not entirely responsible for induction of apoptosis and other mechanisms are involved. Hsp70 knockdown resulted in high levels of ...[more]