Ontology highlight
ABSTRACT:
SUBMITTER: Houser JR
PROVIDER: S-EPMC3397415 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Houser John R JR Ford Eintou E Nagiec Michal J MJ Errede Beverly B Elston Timothy C TC
Molecular systems biology 20120605
All cells must detect and respond to changes in their environment, often through changes in gene expression. The yeast pheromone pathway has been extensively characterized, and is an ideal system for studying transcriptional regulation. Here we combine computational and experimental approaches to study transcriptional regulation mediated by Ste12, the key transcription factor in the pheromone response. Our mathematical model is able to explain multiple counterintuitive experimental results and l ...[more]