Ontology highlight
ABSTRACT:
SUBMITTER: Schmidt EF
PROVIDER: S-EPMC3397430 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Cell 20120501 5
Our understanding of current treatments for depression, and the development of more specific therapies, is limited by the complexity of the circuits controlling mood and the distributed actions of antidepressants. Although the therapeutic efficacy of serotonin-specific reuptake inhibitors (SSRIs) is correlated with increases in cortical activity, the cell types crucial for their action remain unknown. Here we employ bacTRAP translational profiling to show that layer 5 corticostriatal pyramidal c ...[more]