Age-related variation in immunity in a wild mammal population.
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ABSTRACT:
SUBMITTER: Nussey DH
PROVIDER: S-EPMC3397677 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Publications
Age-related variation in immunity in a wild mammal population.
Nussey Daniel H DH Watt Kathryn K Pilkington Jill G JG Zamoyska Rose R McNeilly Tom N TN
Aging cell 20111228 1
Age-related changes in immunity are well documented in humans and laboratory mammals. Using blood samples collected from wild Soay sheep, we show that pronounced differences in T-cell subsets and inflammatory markers amongst age classes are also evident under natural conditions. These shifts parallel those observed in mammals experiencing protected environments. We found progressive declines in the proportion of naïve CD4 T cells with age, a precipitous drop in γδ T cells after the second year o ...[more]
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