Ontology highlight
ABSTRACT:
SUBMITTER: Namiki K
PROVIDER: S-EPMC3397849 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Namiki Kana K Matsunaga Hirofumi H Yoshioka Kento K Tanaka Kensuke K Murata Kazuya K Ishida Junji J Sakairi Akira A Kim Jundal J Tokuhara Naoki N Shibakawa Nobuhiko N Shimizu Motohisa M Wada Yukinori Y Tokunaga Yasunori Y Shigetomi Manabu M Hagihara Masahiko M Kimura Sadao S Sudo Tatsuhiko T Fukamizu Akiyoshi A Kasuya Yoshitoshi Y
The Journal of biological chemistry 20120525 29
One of the mitogen-activated protein kinases, p38, has been found to play a crucial role in various inflammatory responses. In this study, we analyzed the roles of p38α in multiple sclerosis, using an animal model, experimental autoimmune encephalomyelitis (EAE). p38α(+/-) mice (p38α(-/-) showed embryonic lethality) showed less severe neurological signs than WT mice. Adoptive transfer of lymph node cells (LNC) from sensitized WT mice with MOG(35-55) to naive WT-induced EAE was much more severe c ...[more]