Ontology highlight
ABSTRACT:
SUBMITTER: Depetris RS
PROVIDER: S-EPMC3397850 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Depetris Rafael S RS Julien Jean-Philippe JP Khayat Reza R Lee Jeong Hyun JH Pejchal Robert R Katpally Umesh U Cocco Nicolette N Kachare Milind M Massi Evan E David Kathryn B KB Cupo Albert A Marozsan Andre J AJ Olson William C WC Ward Andrew B AB Wilson Ian A IA Sanders Rogier W RW Moore John P JP
The Journal of biological chemistry 20120529 29
The trimeric envelope glycoprotein complex (Env) is the focus of vaccine development programs aimed at generating protective humoral responses to human immunodeficiency virus type 1 (HIV-1). N-Linked glycans, which constitute almost half of the molecular mass of the external Env domains, produce considerable structural heterogeneity and are a major impediment to crystallization studies. Moreover, by shielding the peptide backbone, glycans can block attempts to generate neutralizing antibodies ag ...[more]