Ontology highlight
ABSTRACT:
SUBMITTER: Douglas AD
PROVIDER: S-EPMC3398130 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Douglas A D AD Andrews L L Draper S J SJ Bojang K K Milligan P P Gilbert S C SC Imoukhuede E B EB Hill A V S AV
The Journal of infectious diseases 20110501 9
Naturally acquired immunity to Plasmodium falciparum's asexual blood stage reduces parasite multiplication at microscopically detectable densities. The effect of natural immunity on initial prepatent parasite multiplication during the period following a new infection has been uncertain, contributing to doubt regarding the utility of experimental challenge models for blood-stage vaccine trials. Here we present data revealing that parasite multiplication rates during the initial prepatent period i ...[more]