Ontology highlight
ABSTRACT:
SUBMITTER: Mumprecht V
PROVIDER: S-EPMC3398152 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Mumprecht Viviane V Honer Michael M Vigl Benjamin B Proulx Steven T ST Trachsel Eveline E Kaspar Manuela M Banziger-Tobler Nadja E NE Schibli Roger R Neri Dario D Detmar Michael M
Cancer research 20101026 21
Metastasis to regional lymph nodes (LN) is a prognostic indicator for cancer progression. There is a great demand for sensitive and noninvasive methods to detect metastasis to LNs. Whereas conventional in vivo imaging approaches have focused on the detection of cancer cells, lymphangiogenesis within tumor-draining LNs might be the earliest sign of metastasis. In mouse models of LN lymphangiogenesis, we found that systemically injected antibodies to lymphatic epitopes accumulated in the lymphatic ...[more]