Ontology highlight
ABSTRACT:
SUBMITTER: Chang KH
PROVIDER: S-EPMC3398168 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Chang Kai-Hsin KH Fang Xiangdong X Wang Hao H Huang Andy A Cao Hua H Yang Yadong Y Bonig Halvard H Stamatoyannopoulos John A JA Papayannopoulou Thalia T
Stem cell reviews and reports 20130801 4
Human embryonic stem cells provide an alternative to using human embryos for studying developmentally regulated gene expression. The co-expression of high levels of embryonic ε and fetal γ globin by the hESC-derived erythroblasts allows the interrogation of ε globin regulation at the transcriptional and epigenetic level which could only be attained previously by studying cell lines or transgenic mice. In this study, we compared the histone modifications across the β globin locus of the undiffere ...[more]