Ontology highlight
ABSTRACT:
SUBMITTER: Martel MA
PROVIDER: S-EPMC3398391 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Martel Marc-André MA Ryan Tomás J TJ Bell Karen F S KF Fowler Jill H JH McMahon Aoife A Al-Mubarak Bashayer B Komiyama Noboru H NH Horsburgh Karen K Kind Peter C PC Grant Seth G N SG Wyllie David J A DJ Hardingham Giles E GE
Neuron 20120501 3
It is currently unclear whether the GluN2 subtype influences NMDA receptor (NMDAR) excitotoxicity. We report that the toxicity of NMDAR-mediated Ca(2+) influx is differentially controlled by the cytoplasmic C-terminal domains of GluN2B (CTD(2B)) and GluN2A (CTD(2A)). Studying the effects of acute expression of GluN2A/2B-based chimeric subunits with reciprocal exchanges of their CTDs revealed that CTD(2B) enhances NMDAR toxicity, compared to CTD(2A). Furthermore, the vulnerability of forebrain ne ...[more]