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Computational analysis of human and mouse CREB3L4 Protein.

ABSTRACT: CREB3L4 is a member of the CREB/ATF transcription factor family, characterized by their regulation of gene expression through the cAMP-responsive element. Previous studies identified this protein in mice and humans. Whereas CREB3L4 in mice (referred to as Tisp40) is found in the testes and functions in spermatogenesis, human CREB3L4 is primarily detected in the prostate and has been implicated in cancer. We conducted computational analyses to compare the structural homology between murine Tisp40? human CREB3L4. Our results reveal that the primary and secondary structures of the two proteins contain high similarity. Additionally, predicted helical transmembrane structure reveals that the proteins likely have similar structure and function. This study offers preliminary findings that support the translation of mouse Tisp40? findings into human models, based on structural homology.

SUBMITTER: Velpula KK

PROVIDER: S-EPMC3398783 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature

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Computational analysis of human and mouse CREB3L4 Protein.

Velpula Kiran Kumar KK Rehman Azeem Abdul AA Chigurupati Soumya S Sanam Ramadevi R Inampudi Krishna Kishore KK Akila Chandra Sekhar CS

Bioinformation 20120628 12

CREB3L4 is a member of the CREB/ATF transcription factor family, characterized by their regulation of gene expression through the cAMP-responsive element. Previous studies identified this protein in mice and humans. Whereas CREB3L4 in mice (referred to as Tisp40) is found in the testes and functions in spermatogenesis, human CREB3L4 is primarily detected in the prostate and has been implicated in cancer. We conducted computational analyses to compare the structural homology between murine Tisp40 ...[more]

PMID: 22829733

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