Variation in mitochondrial genome primary sequence among whole-genome-sequenced strains of Neurospora crassa.

ABSTRACT: Eighteen classical mutant strains of Neurospora crassa were subject to whole genome sequence analysis and the mitochondrial genome is analyzed. Overall, the mitochondrial genomes of the classical mutant strains are 99.45 to 99.98 % identical to the reference genome. Two-thirds of the SNPs and three-fourths of indels identified in this analysis are shared among more than one strain. Most of the limited variability in mitochondrial genome sequence is neutral with regard to protein structure. Despite the fact that the mitochondrial genome is present in multiple copies per cell, many of the polymorphisms were homozygous within each strain. Conversely, some polymorphisms, especially those associated with large scale rearrangements are only present in a fraction of the reads covering each region

SUBMITTER: McCluskey K 

PROVIDER: S-EPMC3399107 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature