Borrelidin modulates the alternative splicing of VEGF in favour of anti-angiogenic isoforms.
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ABSTRACT:
SUBMITTER: Woolard J
PROVIDER: S-EPMC3399765 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Publications
Borrelidin modulates the alternative splicing of VEGF in favour of anti-angiogenic isoforms.
Woolard Jeanette J Vousden William W Moss Steven J SJ Krishnakumar Arjun A Gammons Melissa Vr MV Nowak David G DG Dixon Neil N Micklefield Jason J Spannhoff Astrid A Bedford Mark T MT Gregory Matthew A MA Martin Christine J CJ Leadlay Peter F PF Zhang Ming Q MQ Harper Steven J SJ Bates David O DO Wilkinson Barrie B
Chemical science 20110201 2
The polyketide natural product borrelidin 1 is a potent inhibitor of angiogenesis and spontaneous metastasis. Affinity biopanning of a phage display library of colon tumor cell cDNAs identified the tandem WW domains of spliceosome-associated protein formin binding protein 21 (FBP21) as a novel molecular target of borrelidin, suggesting that borrelidin may act as a modulator of alternative splicing. In support of this idea, 1, and its more selective analog 2, bound to purified recombinant WW doma ...[more]
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