Ontology highlight
ABSTRACT:
SUBMITTER: Guler G
PROVIDER: S-EPMC3400504 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Guler Gulnur G Balci Serdar S Costinean Stefan S Ussakli Cigdem Himmetoglu CH Irkkan Cigdem C Suren Dinc D Sari Ebru E Altundag Kadri K Ozisik Yavuz Y Jones Susie S Bacher Jason J Shapiro Charles L CL Huebner Kay K
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 20120302 7
It has been reported previously that: (1) normal-breast epithelial cells that are CD24-/44+ express higher levels of stem/progenitor cell-associated genes; (2) cancer cells that have undergone epithelial to mesenchymal transition display CD24-/44+ cell-surface expression, a marker for breast cancer stem cells; (3) loss of E-cadherin is a preliminary step in epithelial to mesenchymal transition; and (4) vimentin is a marker of mesenchymal phenotype. We hypothesized that stem cell subpopulations w ...[more]