Dynamical systems approach to endothelial heterogeneity.
Ontology highlight
ABSTRACT:
SUBMITTER: Regan ER
PROVIDER: S-EPMC3400545 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Publications
Dynamical systems approach to endothelial heterogeneity.
Regan Erzsébet Ravasz ER Aird William C WC
Circulation research 20120601 1
Endothelial cells display remarkable phenotypic heterogeneity. An important goal is to elucidate the scope and mechanisms of endothelial heterogeneity and to use this information to develop vascular bed-specific therapies. We reexamine our current understanding of the molecular basis of endothelial heterogeneity. We introduce multistability as a new explanatory framework in vascular biology. We draw on the field of nonlinear dynamics to propose a dynamical systems framework for modeling multista ...[more]
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