Ontology highlight
ABSTRACT:
SUBMITTER: EL-Manzalawy Y
PROVIDER: S-EPMC3400677 | biostudies-literature | 2011 Jul-Aug
REPOSITORIES: biostudies-literature
EL-Manzalawy Yasser Y Dobbs Drena D Honavar Vasant V
IEEE/ACM transactions on computational biology and bioinformatics 20110701 4
Reliably predicting the ability of antigen peptides to bind to major histocompatibility complex class II (MHC-II) molecules is an essential step in developing new vaccines. Uncovering the amino acid sequence correlates of the binding affinity of MHC-II binding peptides is important for understanding pathogenesis and immune response. The task of predicting MHC-II binding peptides is complicated by the significant variability in their length. Most existing computational methods for predicting MHC- ...[more]