Ontology highlight
ABSTRACT:
SUBMITTER: Mourot A
PROVIDER: S-EPMC3401033 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Mourot Alexandre A Kienzler Michael A MA Banghart Matthew R MR Fehrentz Timm T Huber Florian M E FM Stein Marco M Kramer Richard H RH Trauner Dirk D
ACS chemical neuroscience 20110609 9
Photochromic channel blockers provide a conceptually simple and convenient way to modulate neuronal activity with light. We have recently described a family of azobenzenes that function as tonic blockers of K(v) channels but require UV-A light to unblock and need to be actively switched by toggling between two different wavelengths. We now introduce red-shifted compounds that fully operate in the visible region of the spectrum and quickly turn themselves off in the dark. Furthermore, we have dev ...[more]