Lactose intolerance: diagnosis, genetic, and clinical factors.
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ABSTRACT:
SUBMITTER: Mattar R
PROVIDER: S-EPMC3401057 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
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Lactose intolerance: diagnosis, genetic, and clinical factors.
Mattar Rejane R de Campos Mazo Daniel Ferraz DF Carrilho Flair José FJ
Clinical and experimental gastroenterology 20120705
Most people are born with the ability to digest lactose, the major carbohydrate in milk and the main source of nutrition until weaning. Approximately 75% of the world's population loses this ability at some point, while others can digest lactose into adulthood. This review discusses the lactase-persistence alleles that have arisen in different populations around the world, diagnosis of lactose intolerance, and its symptomatology and management. ...[more]
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2016-03-25 | GSE69979 | GEO
Project description:Lactose intolerance refers to symptoms related to the consumption of lactose-containing dairy foods, which are the most common source for this disaccharide. While four causes are described, the most common is the genetically-determined adult onset lactose maldigestion due to loss of intestinal lactase governed by control of the gene by a 14,000 kb promoter region on chromosome 2. Gastrointestinal symptoms from lactose have expanded to include systemic effects and have also been confounded by other food intolerances or functional gastrointestinal disorders. Partly because lactose maldigestion is often interpreted as lactose intolerance (symptoms), focus of therapy for these symptoms starts with lactose restriction. However, withholding of dairy foods completely is not appropriate due to a more favorable impact on health. Industrial efforts to substitute with plant-based products is not completely successful at this time. This narrative article reviews the complexities of the perception of lactose intolerance, its epidemiology, and pathogenesis. Treatments are discussed, including the inappropriateness of dairy avoidance. In conjunction, effects of dairy products on 19 common diseases are reviewed. Different methods of treatment, lactose-reduced products, plant-based dairy substitutes, adaptation, prebiotics, exogenous lactase, probiotics, and some other dietary interventions are further discussed.
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Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
2016-03-25 | E-GEOD-69979 | biostudies-arrayexpress
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