Ontology highlight
ABSTRACT:
SUBMITTER: De Mello RA
PROVIDER: S-EPMC3401159 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Rare tumors 20120401 2
Metastatic melanoma (MM) presents a treatment challenge to oncologists worldwide. Dacarbazine is the first line chemotherapy treatment for MM, though the overall response rates are very poor. Recently, the v-raf murine sarcoma viral oncogene homolog B1 (BRAF) V600 mutation was found to play a main role in MM. This mutation is present in 40-60% of melanoma patients. Vemurafenib is a BRAF kinase inhibitor that showed impressive results in phase I-III trials and was thus recently approved for the t ...[more]